Having a medical condition is difficult enough, but if that condition doesn’t respond to medical treatment, life can become a constant battle. Refractory epilepsy is also known as uncontrolled or drug-resistant epilepsy. This means that a person who is suffering from refractory epilepsies is not responding to traditional medicine and thus is unable to effectively manage his or her neurological disorder.
Our pick for Best Customer Experience is Fab CBD, a brand that offers high-quality CBD products at a reasonable price and provides additional perks for shoppers. The company’s CBD oil is available in four concentrations, ranging from 240mg to 1,500mg, which makes the oil suitable for those with light to moderate insomnia symptoms. The oil is available in natural, mint, and citrus flavors; prices range from 11 to 26 cents per mg, depending on the concentration. Fab CBD also offers edible gummies and a CBD topical oil.
CBD has been touted for a wide variety of health issues, but the strongest scientific evidence is for its effectiveness in treating some of the cruelest childhood epilepsy syndromes, such as Dravet syndrome and Lennox-Gastaut syndrome (LGS), which typically don’t respond to antiseizure medications. In numerous studies, CBD was able to reduce the number of seizures, and in some cases it was able to stop them altogether. Videos of the effects of CBD on these children and their seizures are readily available on the Internet for viewing, and they are quite striking. Recently the FDA approved the first ever cannabis-derived medicine for these conditions, Epidiolex, which contains CBD.
Separation in hemp oil products is completely natural and to be expected. Some bottles are impossible to see into (which is good — dark bottles help block light for optimal shelf life), but if you can, take note of how the oil tends to settle onto the bottom. Once you start shaking, it quickly blends. I can’t stress how important this step is. If you don’t shake it, you’ll likely end up consuming straight grapeseed and coconut oil. It’s not the tastiest experience, and won’t be very beneficial for you either.
Customer Service: We’ve always received fast, informative responses to our queries about products and practices, but there are definitely customers out there who have not. A quick perusal of reviews shows customers who had issues with unaddressed orders. It’s hard to know exactly what the problem is in these situations, but the company’s strict return policy (seven days for unopened products only) probably doesn’t help. It should be noted that the company has a solid base of very satisfied customers as well.
For those customers looking to balance cost and potency, three of our popular brands, RSHO™, Dixie Botanicals®, and Cibdex®, carry a line of CBD hemp oil capsules with a moderate 25 mg of CBD per capsule. These medium potency capsules contain the same CBD hemp oil as our other products, making it simple to take your CBD supplements with you. These bottles fit easily into an overnight bag or briefcase and are never out of place in a bathroom medicine cabinet or office drawer, ensuring your CBD hemp oil supplements are within reach.
Dispensaries: In states where marijuana is legal for recreational use, dispensaries are a common sight. They are much rarer in states with more restrictions. In states that permit the use of medical marijuana, hemp-based CBD oils do not normally require a prescription but marijuana-based oils do. Like brick-and-mortar locations, dispensaries offer more customer service. However, as noted, this may not be an option depending on the buyer’s state of residence. Also, CBD oil prices tend to be significantly higher at dispensaries.
Consume CBD oil via edibles to enjoy a sweet treat. There are many edible products available for purchase that contain CBD oil as an ingredient. These are often in the form of gummies or other candies, but also come as an edible liquid that you can mix into foods, such as smoothies. If you live in a state where it’s legal, go online and choose whichever edibles sound good to you. After purchasing, make sure to read the instructions and take them as directed.[2]
Tinctures – Typically tinctures are small glass or plastic “dropper” bottles that have cannabidiol oil mixed with a preserving solution such as alcohol. Tinctures were very a very common way to ingest botanical oils prior to the industrial revolution and are experiencing a resurgence in popularity as more people are looking for natural remedies. Tinctures with droppers allow you to put a few drops in your tea, under your tongue, or to bake the oil directly into your food.
Consume CBD oil via edibles to enjoy a sweet treat. There are many edible products available for purchase that contain CBD oil as an ingredient. These are often in the form of gummies or other candies, but also come as an edible liquid that you can mix into foods, such as smoothies. If you live in a state where it’s legal, go online and choose whichever edibles sound good to you. After purchasing, make sure to read the instructions and take them as directed.[2]

Ranging from irritating to debilitating, joint pain can be tricky to treat. If your pain is mild, ibuprofen or acetaminophen might be adequate. But the worse it gets, the more likely you are to be prescribed antidepressants, muscle relaxants, or even opioids. Because of the side effects associated with these prescription medications, there has been quite a bit of research on CBD and joint pain — with promising results. Here are a few studies that point to CBD’s potential:
The furry subjects, 277 Wistar rats, were given a dose of CBD immediately after receiving a small electric shock. The CBD-treated subjects were found to spend less time frozen in fear when reintroduced to the context of the fearful event. This means the CBD disrupted consolidation (or more simply put: memory strengthening) of their specific and long-term fear memory.
In one survey, parents of children who suffer from treatment-resistant epilepsy and use CBD were asked about the benefits. 19 parents were included, 84% of which said that CBD reduced the frequency of seizures. Two parents said that CBD completely resolved seizures. Parents also reported improved alertness, sleep, and mood. Some side effects were drowsiness and fatigue [54].
Although CBD oils aren’t regulated by the FDA, purchasing products stateside from one of the nine states where recreational and medical cannabis use is legal will likely result in a higher-quality product than buying one made with hemp-derived CBD oil imported from abroad, says Martin Lee, director of Project CBD, a nonprofit that promotes medical research into CBD.
In addition to acting on the brain, CBD influences many body processes. That’s due to the endocannabinoid system (ECS), which was discovered in the 1990s, after scientists started investigating why pot produces a high. Although much less well-known than the cardiovascular, reproductive, and respiratory systems, the ECS is critical. “The ECS helps us eat, sleep, relax, forget what we don’t need to remember, and protect our bodies from harm,” Marcu says. There are more ECS receptors in the brain than there are for opioids or serotonin, plus others in the intestines, liver, pancreas, ovaries, bone cells, and elsewhere.
Research on CBD and anxiety has generally looked at cannabis as a whole product, not as CBD as a standalone compound. Some studies suggest that it can help with anxiety: like this 2011 study that suggests CBDcan reduce social anxiety or this 2015 review that says CBD could be promising for many forms of anxiety. It’s also important to consider whether the CBD comes from the cannabis plant and therefore may include THC, a cannabinoid that for some, induces anxiety. Read our comprehensive article on CBD and anxiety, here.
CBD oil is not legal everywhere. It is banned/restricted by countries such as UAE, Dubai, and Saudi Arabia. Although CBD oil is illegal in many of the US states too, some have legalized its use for medicinal purposes. While the number would be ever-changing, as of 2016 there are 17 states in the US which have legalized the use of low THC, high CBD products for medical reasons in limited situations. These states include Alabama, Georgia, Iowa, Kentucky, Florida, Mississippi, Louisiana, Missouri, North Carolina, Oklahoma, South Carolina, Wisconsin, Wyoming, Tennessee, Texas, Utah, and Virginia. It is advisable to consult your local health specialist before use.
Unlike THC, CBD will not make you high. That said, this doesn’t mean CBD is not at all psychoactive, as many assert, says Jahan Marcu, PhD, director of experimental pharmacology and behavior at the International Research Center on Cannabis and Mental Health in New York City: “CBD does change cognition. It affects mood, which is why people take it for anxiety. And some find that it makes them more alert.”
Vape Pens – Perhaps the easiest way to get the CBD Oil into your body is through a vape pen. A vape pen is about the size of an ink pen but has a CBD oil cartridge with a heating element. Many people like vape pens because there is very little in the way of odor after using it and it allows for a lot of discretion because it can be pulled out of your pocket and used on demand.
To make matters more confusing, nine states (including California, Washington, and Colorado) let residents buy cannabis-based products with or without THC. Nearly two dozen other “medical marijuana states” allow the sale of cannabis, including capsules, tinctures, and other items containing CBD or THC, at licensed dispensaries to people whose doctors have certified that they have an approved condition (the list varies by state but includes chronic pain, PTSD, cancer, autism, Crohn’s disease, and multiple sclerosis). Sixteen more states legalized CBD for certain diseases.
High blood pressure is a globally ubiquitous issue. This study explores the connection between CBD and a reduction in blood pressure. It is particularly unique as it is noted that “there are no dedicated studies in humans to date, to our knowledge, looking at the effect of CBD on either resting cardiovascular measurement or on the responses to stress, with continuous monitoring of CV parameters.”

Currently, the only CBD product approved by the Food and Drug Administration is a prescription oil called Epidiolex. It's approved to treat two types of epilepsy. Aside from Epidiolex, state laws on the use of CBD vary. While CBD is being studied as a treatment for a wide range of conditions, including Parkinson's disease, schizophrenia, diabetes, multiple sclerosis and anxiety, research supporting the drug's benefits is still limited.


This is the second time Moon Mother Hemp Company has placed among the top five brands on our ranking. The Colorado-based company, which was founded about a year ago, sets the bar very high for quality (including USDA-certified organic hemp) without charging the moon for its products. Their tinctures taste so good, you may be sad you don’t need more.  
CBD is extracted from marijuana plants as either an oil or powder. These can be mixed into creams or gels. They can be put into capsules and taken orally, or rubbed on your skin. The multiple sclerosis drug nabiximols is sprayed as a liquid into your mouth. How CBD should be used depends largely on what it’s being used for. Talk to your doctor before using CBD oil. It hasn’t been approved by the U.S. Food and Drug Administration (FDA) for any medical uses, and it can have side effects.
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