The studies on CBD for headache pain are still in their infancy, but with promising results so far. A 2017 study published in the Cannabis and Cannabinoid Research Journal worked with 26 people who were experiencing rebound headaches. The pain management results were better for the cannabis-nabilone formula over either ibuprofen or nabilone alone. (As a nerdy side note, the article is a great read if you’re interested in the history of cannabis as a pain reliever.)
There are more than 80 cannabinoids found in cannabis plants, with THC being the primary one, followed by CBD. However, in the hemp plant, which is a different strain of the species Cannabis sativa, CBD is the main active ingredient, and THC is barely present, making its use and legality more widespread. The reason that CBD is such an effective form of support for human health is due to the body’s endogenous cannabinoid system. This regulatory structure of the body has millions of cannabinoid receptors in the brain and nervous system, which react not only to plant-derived cannabinoids (such as hemp and marijuana) but also to natural cannabinoids produced within our body. When hemp oil is used and processed by the body, it is effectively boosting the function of the endocannabinoid system, helping our body regulate itself in many different ways.
CBD was also found to disrupt the consolidation of generalized fear memories when administered immediately after the acquisition of such fear memory. Interestingly, the timing of the administration of CBD was vital as the results demonstrated that delayed administration of the CBD dose did not have the same effective result that immediate administration did.
A major theme when reviewing the research on the best CBD for pain is the need for more large-scale clinical trials on CBD in isolation from other cannabinoids like THC. That’s not to say that THC is bad. It’s developed a stigma because it makes you high, which makes people think of hippies and the sixties and maybe your perennially stoned neighbor who clearly doesn’t have his stuff together. But THC also comes with a pretty respectable list of benefits. These range from antiemetic (anti-nausea) and anti-inflammatory effects to appetite stimulation.
Luckily, it’s possible to procure CBD oil that has no THC in it. Products made from CBD Isolate or Broad Spectrum CBD can be good options if you want to avoid THC. In fact, some of the best CBD products for pain include topical salves that can be made from isolate CBD oil. Just be sure to check out third-party lab reports to ensure you’re getting exactly what you pay for. And keep your eyes peeled for future research on CBD for pain.
But scientists have found that CBD doesn’t bind well with endocannabinoid receptors. Instead, CBD influences the system indirectly. This creates many benefits, which is why you’ll hear of CBD as a treatment for so many different medical conditions. And, unlike THC, it won’t make you high. When it comes to pain, we know that CBD has multiple functions. First, it influences neurotransmitters and receptors. One receptor known to be involved with pain and inflammation is called TRPV1 — also known as a vanilloid receptor. CBD binds to the TRPV1 receptor, influencing the way you perceive pain. CBD can also affect the production of neurotransmitters like serotonin and glutamate, which are related to pain sensation.
The effects of CBD on receptors in the immune system may help reduce overall inflammation in the body. In turn, CBD oil may offer benefits for acne management. A human study published in the Journal of Clinical Investigationfound that the oil prevented activity in sebaceous glands. These glands are responsible for producing sebum, a natural oily substance that hydrates the skin. Too much sebum, however, can lead to acne.
CBD is a chemical found in marijuana. CBD doesn't contain tetrahydrocannabinol (THC), the psychoactive ingredient found in marijuana that produces a high. The usual CBD formulation is oil, but CBD is also sold as an extract, a vaporized liquid and an oil-based capsule. Food, drinks and beauty products are among the many CBD-infused products available online.