Our bodies are thought to produce endocannabinoids by the billions every day. “We always thought the ‘runner’s high’ was due to the release of dopamine and endorphins. But now we know the euphoria is also from an endocannabinoid called anandamide,” its name derived from the Sanskrit word for bliss, says Joseph Maroon, MD, clinical professor and vice chairman of neurosurgery at the University of Pittsburgh Medical Center. We produce these natural chemicals all day, but they fade quickly because enzymes pop up to destroy them. That’s where CBD comes in: By blocking these enzymes, CBD allows the beneficial compounds to linger.
However, before the villainization of hemp, it was widely accepted as a very useful plant (3). From biofuel from its seeds to medicine from its leaves, it ought to be a core crop grown by farmers across the United States and beyond. However, for reasons too numerous to discuss in this article, issues of legality and federal restrictions have put a stop to that idea for the time being.
Cannabidiol, more commonly known as CBD, is one of 113 known cannabinoids found in cannabis. But unlike its better-known counterpart THC (tetrahydrocannabinol), responsible for cannabis’ mind-altering effects, extensive research suggests that CBD is not psychoactive, and with none of the often-damaging side effects accompanying synthetic pharmaceuticals.
Non-THC CBD oils can be highly effective, and are suitable for employees who face random or routine drug tests. Our top pick for this category is the Medterra CBD Oil Tincture, which contains 99.6% CBD and MCT oil (also known as coconut oil extract) without any traces of THC. The oil is derived from hemp plants that are free of GMOs and pesticides, as well. All third-party testing results for the oil are accessible through Medterra’s official product page.
Tinctures – Typically tinctures are small glass or plastic “dropper” bottles that have cannabidiol oil mixed with a preserving solution such as alcohol. Tinctures were very a very common way to ingest botanical oils prior to the industrial revolution and are experiencing a resurgence in popularity as more people are looking for natural remedies. Tinctures with droppers allow you to put a few drops in your tea, under your tongue, or to bake the oil directly into your food.
High-potency CBD oils are most suitable for people experiencing strong, insomnia, chronic aches and pains, anxiety/depression symptoms, and other conditions that necessitate stronger effects. Our top pick for this category is the Lab Grade CBD Oil from Spruce, which comes in a 30mL bottle with a concentration of 2,400mg. Each full dropper of oil contains roughly 80mg of CBD, which can be an effective dose for those with severe discomfort or symptoms.
Apply CBD oil topically if you have localized pain. Look online for CBD topical skin creams if you live where it’s legal. The container will likely only display the total amount of CBD that’s in the product, so there’s no need to measure out a specific dosage. Simply use your finger to scoop up enough of the product to cover the area of skin you want to treat and rub it in really well.[4]
In addition to all the benefits we’ve already discussed, CBD has been proven to have antioxidant and neuroprotective effects. This means that it helps repair the damage from oxidative stress, which is believed to be a primary cause of diseases like Alzheimer’s, Parkinson’s, ALS — even heart disorders and some forms of cancer. This is a hugely beneficial effect of CBD.

Apply CBD oil topically if you have localized pain. Look online for CBD topical skin creams if you live where it’s legal. The container will likely only display the total amount of CBD that’s in the product, so there’s no need to measure out a specific dosage. Simply use your finger to scoop up enough of the product to cover the area of skin you want to treat and rub it in really well.[4]

At the top of our ranking is Portland-based Lazarus Naturals, which has honed a reputation for high-quality, affordable CBD. Their consciously crafted CBD is sourced from organic, Oregon-grown hemp which the company controls from seed to sale. With low prices, a robust assistance program, free shipping, and a 30-day, no questions asked return policy, you really can’t go wrong with Lazarus Naturals.
Online Retailers: Most CBD oils are sold through online retailers. These establishments tend to have the widest product range, and many offer free doorstep delivery. Online retailers also frequently post product reviews, allowing buyers to compare different oils based on customer experiences to determine which is best for them. These reviews can also be used to evaluate the retailer based on customer service, delivery, and product quality.
There’s still a lot of unknown territory, but early evidence for CBD’s efficacy is more than enough to justify further large-scale clinical studies — some of which are already in the works. These studies also point to the variety of effective ways to take CBD. This is an important point to keep in mind if you find yourself shopping for CBD products and wondering if the best CBD for pain is a topical, a tincture, or a vape product.
CBD is readily obtainable in most parts of the United States, though its exact legal status is in flux. All 50 states have laws legalizing CBD with varying degrees of restriction, and while the federal government still considers CBD in the same class as marijuana, it doesn’t habitually enforce against it. In December 2015, the FDA eased the regulatory requirements to allow researchers to conduct CBD trials. Currently, many people obtain CBD online without a medical cannabis license. The government’s position on CBD is confusing, and depends in part on whether the CBD comes from hemp or marijuana. The legality of CBD is expected to change, as there is currently bipartisan consensus in Congress to make the hemp crop legal which would, for all intents and purposes, make CBD difficult to prohibit.
Hemp oil does have a number of uses and is often marketed as a cooking oil or a product that is good for moisturizing the skin. It is also used in the production of certain soaps, shampoos, and foods. It is also a basic ingredient for bio-fuel and even a more sustainable form of plastic. Hemp has been cultivated and used for roughly 10,000 years, and it definitely has useful purposes. However, a lack of cannabinoids, namely CBD, means that it has little therapeutic value.
The science behind CBD is in the relatively early stages. As a cannabinoid, we know that CBD interacts with receptors in your endocannabinoid system. The endocannabinoid system is integrated throughout your body — and this widespread, whole-body interaction creates a broad range of effects. Hence, the long list of possible benefits.   We may still be in the early stages of discovery, but there’s plenty of scientific studies and anecdotal evidence that CBD provides relief for an array of ailments. Here’s a non-exhaustive list of some potential benefits of CBD oil:
Cannabidiol, or CBD for short, is a phyto-cannabinoid found in cannabis plants. However, it does not cause the same psychoactive effects as other naturally occurring cannabinoids (such as tetrahydrocannabinol, or THC). CBD induces feelings of sleepiness and tranquility, making it suitable for insomnia and other sleep disorders; CBD can be used to alleviate symptoms of epilepsy, diabetes, and anxiety disorders, as well. Legality is an issue for some; all 50 states have laws governing the sale, possession, and use of CBD, and they vary significantly (see the table below for a full analysis).

Hemp oil does have a number of uses and is often marketed as a cooking oil or a product that is good for moisturizing the skin. It is also used in the production of certain soaps, shampoos, and foods. It is also a basic ingredient for bio-fuel and even a more sustainable form of plastic. Hemp has been cultivated and used for roughly 10,000 years, and it definitely has useful purposes. However, a lack of cannabinoids, namely CBD, means that it has little therapeutic value.

×