CBD hemp oil has a huge range of potential health benefits and uses, including reducing pain, soothing anxiety, fighting chronic diseases, improving mood, eliminating depression, preventing inflammatory arthritis, protecting the immune system, balancing the metabolism, aiding sleep disorders, and healing the skin, among others. CBD oil can also be used in many different ways and has a variety of applications for natural health.

Transparency: Fab’s website features third-party lab results for most products. They only have a lab test for one of their tinctures though (which shows results for cannabinoid potency, as well as contaminants like pesticides). Customer service pointed out that the same CBD oil is used for all their products, but since potencies do vary, we appreciate companies that show potency testing for all products.

Vaporizers – Many state-licensed cannabis dispensaries offer high CBD strains of cannabis flower. This allows for reduced risk of paranoia while allowing for a high medicinal dose of CBD. Vaporizers are used to heat up the flower and remove the properties or compounds of the plant that you are looking for without combustion or smoking. Vaporizers use convection much like a convection oven.
CBD oil is not legal everywhere. It is banned/restricted by countries such as UAE, Dubai, and Saudi Arabia. Although CBD oil is illegal in many of the US states too, some have legalized its use for medicinal purposes. While the number would be ever-changing, as of 2016 there are 17 states in the US which have legalized the use of low THC, high CBD products for medical reasons in limited situations. These states include Alabama, Georgia, Iowa, Kentucky, Florida, Mississippi, Louisiana, Missouri, North Carolina, Oklahoma, South Carolina, Wisconsin, Wyoming, Tennessee, Texas, Utah, and Virginia. It is advisable to consult your local health specialist before use.
A newcomer to our CBD oils ranking, RE: Botanicals is no stranger to hemp. Founded by John Roulac, a long-time hemp advocate and founder of the organic superfoods brand Nutiva, RE: Botanicals is one of the only CBD brands to earn the USDA organic seal. They deserve a shout-out for prioritizing regenerative agriculture, while keeping prices reasonable.   
Lisa Hamilton, a jeweler and doula in Brooklyn, NY, knows about the side effects. She recently tried CBD for the shoulder pain that plagued her five years after an accident. Her doctor certified that she was in chronic pain, which under New York State law allowed her to buy from a state dispensary. One Friday, she swallowed two 10-mg capsules, the amount recommended at the dispensary, then took another two on Saturday. “By Sunday, it felt like I’d gotten hit by a truck. Every muscle and joint ached,” Hamilton says. She cut back to one pill a day the following week, but still felt hungover. She stopped after that. 

Third-Party Testing: Once a CBD oil is manufactured, CBD oil companies will often submit their products for third-party tests, which are conducted by non-company personnel to ensure the product is safe for public consumption and meets quality standards.CBD oils should always be accompanied with information about third-party tests; best practice is to avoid oils that do not supply these details.
Ranging from irritating to debilitating, joint pain can be tricky to treat. If your pain is mild, ibuprofen or acetaminophen might be adequate. But the worse it gets, the more likely you are to be prescribed antidepressants, muscle relaxants, or even opioids. Because of the side effects associated with these prescription medications, there has been quite a bit of research on CBD and joint pain — with promising results. Here are a few studies that point to CBD’s potential:
But scientists have found that CBD doesn’t bind well with endocannabinoid receptors. Instead, CBD influences the system indirectly. This creates many benefits, which is why you’ll hear of CBD as a treatment for so many different medical conditions. And, unlike THC, it won’t make you high. When it comes to pain, we know that CBD has multiple functions. First, it influences neurotransmitters and receptors. One receptor known to be involved with pain and inflammation is called TRPV1 — also known as a vanilloid receptor. CBD binds to the TRPV1 receptor, influencing the way you perceive pain. CBD can also affect the production of neurotransmitters like serotonin and glutamate, which are related to pain sensation.
Our Best Value pick is CBDistillery, which offers a full spectrum CBD oil containing naturally occurring cannabinoids and terpenes, along with fatty acid Omega 3, B complex vitamins, and 20 essential amino acids. The oil is derived from non-GMO, U.S.-grown hemp. It also contains trace amounts of fractionated coconut oil for subtle flavoring. All product information and third-party testing results are found on the official CBDistillery product page.
It’s also important to select CBD oil products based on your concentration preferences. Some forms of CBD oil – such as vapors and tinctures – normally have higher-than-average concentrations, whereas sprays and topicals tend to have lower concentrations. Remember: higher concentration means more pronounced effects, but not necessarily mean higher quality.

It’s safe to say that Charlotte’s Web is probably the most recognized CBD brand out there — and it’s not all hype. This company pioneered the CBD industry and made it their mission to de-stigmatize CBD by setting the bar high for transparency. They produce and oversee their organic CBD products from seed to sale, standing behind them with a solid return policy. 

Cannabidiol, or CBD for short, is a natural phyto-cannabinoid (or plant-based chemical compound) found in cannabis plants, including hemp and marijuana. Unlike other cannabinoids — namely tetrahydrocannabinol, or THC — CBD does not produce any psychoactive effects, and will actually counteract these effects to a degree. CBD will induce feelings of sleepiness; for this reason, it can be an effective soporific for people who struggle to fall and/or remain asleep due to insomnia and other sleep disorders.
For some people, however, regular strength CBD just doesn’t cut it. If you’re one of those people, you may require something a lot stronger. If you think that CBD “doesn’t work”, then it’s possible that you might need to step it up to something stronger. Whether you’ll be good with a 1000mg high-strength CBD oil or if you need to step up to the big leagues with the Hemp Bombs 4000mg vape juice is a matter of personal preference. Everyone’s body is different. What works for someone else may not work for you. Experiment and find the perfect dosage that works best for your unique needs.

There is a strong sedative quality to CBD hemp oil, making it a popular remedy for people with insomnia, sleeplessness, interrupted sleep, post-traumatic stress disorder, restless leg disorder, and other night-time issues. Dr. Scott Shannon, Assistant Clinical Professor of Psychiatry at the University of Colorado School of Medicine, USA, published a report in the Permanete Journal, in which he recommended either inhaling a small amount of CBD oil, applying it to one’s chest, or even putting a few drops on one’s pillow to help get a good night’s sleep.

This is the second time Moon Mother Hemp Company has placed among the top five brands on our ranking. The Colorado-based company, which was founded about a year ago, sets the bar very high for quality (including USDA-certified organic hemp) without charging the moon for its products. Their tinctures taste so good, you may be sad you don’t need more.  
Customer Service: We’ve always received fast, informative responses to our queries about products and practices, but there are definitely customers out there who have not. A quick perusal of reviews shows customers who had issues with unaddressed orders. It’s hard to know exactly what the problem is in these situations, but the company’s strict return policy (seven days for unopened products only) probably doesn’t help. It should be noted that the company has a solid base of very satisfied customers as well.
In one survey, parents of children who suffer from treatment-resistant epilepsy and use CBD were asked about the benefits. 19 parents were included, 84% of which said that CBD reduced the frequency of seizures. Two parents said that CBD completely resolved seizures. Parents also reported improved alertness, sleep, and mood. Some side effects were drowsiness and fatigue [54].
Hemp Bombs offers high-strength CBD in the following concentrations: 1000mg, 2000mg, and an *insane* 4000mg. This is in addition to their regular strength products (75mg, 250mg, 300mg). These high-strength CBD oils are available as either flavored e-liquid or a flavorless tank additive if you already have an e-juice flavor that you love. If you’re the type of person who needs a high strength product to feel the effects, the 4000mg bottle of e-liquid will be perfect for you. It costs a pretty penny but it lasts an incredibly long time.
Sub-lingual CBD drops have helped me enormously with sleeping and with radiation damage pain. I have a cancer that spread from the pelvic area to my sacrum and sciatic nerve and whilst the chemo and radiotherapy saved my life I have been taking MST (morphine derivative) for nerve pain ever since. My tumours are presently all quiet and last March I decided I wanted to stop taking the pain relief drugs, fearing dementia. CBD oil was recommended by my son who has arthritis and, for me, it really works. It’s so good to read an article that isn’t put out by a CBD sales site – I wish it could be properly prescribed and regulated (I’m in the UK) in order to have confidence with purity and dosage.
But because all these products are illegal according to the federal government, cannabis advocates are cautious. “By and large, the federal government is looking the other way,” says Paul Armentano, deputy director of the Washington, DC–based National Organization for the Reform of Marijuana Laws (NORML), but until federal laws are changed, “this administration or a future one could crack down on people who produce, manufacture, or use CBD, and the law would be on its side.”

This study combats the notion that CBD causes a THC high by discussing the misinterpretations of prior studies on the subject. In fact, the researchers state that two particular prior studies “have caused much confusion and uncertainty whether oral cannabidiol (CBD) is safe and whether subjects who are treated with CBD run the risk of positive workplace tests [for THC].”


CBD was also found to disrupt the consolidation of generalized fear memories when administered immediately after the acquisition of such fear memory. Interestingly, the timing of the administration of CBD was vital as the results demonstrated that delayed administration of the CBD dose did not have the same effective result that immediate administration did.

Unfortunately due to the disappointing and down right inaccurate position of the federal government in classifying Cannabis as a schedule one drug, most research institutions risk federal funding if they conduct real research on Cannabis. This has dramatically limited the potential for real research by real scientists to be conducted. That research is critical to better understanding the multitude of therapeutic effects of the various chemical constituents found in Cannabis.


Chronic Pain: The body’s ECS plays a role in alleviating and managing pain, so CBD oil can work as a supplement for individuals with medical conditions that cause chronic pain, such as arthritis and multiple sclerosis. CBD oil also increases levels of adenosine in the brain; adenosine is a neurotransmitter that aids cardiovascular function and eases painful inflammation.
CBD oil is not legal everywhere. It is banned/restricted by countries such as UAE, Dubai, and Saudi Arabia. Although CBD oil is illegal in many of the US states too, some have legalized its use for medicinal purposes. While the number would be ever-changing, as of 2016 there are 17 states in the US which have legalized the use of low THC, high CBD products for medical reasons in limited situations. These states include Alabama, Georgia, Iowa, Kentucky, Florida, Mississippi, Louisiana, Missouri, North Carolina, Oklahoma, South Carolina, Wisconsin, Wyoming, Tennessee, Texas, Utah, and Virginia. It is advisable to consult your local health specialist before use.
Of course, there is a different side to the story also. It is true that the studies concluded so far have their limitations, and there is no saying what effects supplementation with CBD for more than 6 months could have. However, they suggest cannabidiol has the potential for treating some mental disorders, like anxiety and depression, seizure disorders like epilepsy, insomnia, and chronic pain.
Our pick for Best Customer Experience is Fab CBD, a brand that offers high-quality CBD products at a reasonable price and provides additional perks for shoppers. The company’s CBD oil is available in four concentrations, ranging from 240mg to 1,500mg, which makes the oil suitable for those with light to moderate insomnia symptoms. The oil is available in natural, mint, and citrus flavors; prices range from 11 to 26 cents per mg, depending on the concentration. Fab CBD also offers edible gummies and a CBD topical oil.

CBD has been in the news before, as a possible treatment for epilepsy. Research is still in its early days. Researchers are testing how much CBD is able to reduce the number of seizures in people with epilepsy, as well as how safe it is. The American Epilepsy Society states that cannabidiol research offers hope for seizure disorders, and that research is currently being conducted to better understand safe use.
“Buying from a reputable manufacturer is crucial, because it matters how the plant is cultivated and processed,” Dr. Maroon says. One clue that a company is cutting corners: too low a cost. Good CBD is pricey—a bottle of high-quality capsules is sold in Cohen’s office for $140. But for many, it’s worth the money. Roth spent $60 on her tiny bottle. But when her energy returned the day she started taking CBD, she decided that was a small price to pay.
CBD works by attaching itself to specific receptors of the body’s own endocannabinoid system. The human body is known to produce cannabinoids of its own, which affect the cannabinoid receptors CB1 and CB2. The CB1 receptors are generally found in the brain, and deal with pain, mood and emotions, movement, appetite, among others. THC acts upon the CB1 receptors. Meanwhile, CB2 receptors are more commonly found throughout the immune system, affecting inflammation and thus pain. CBD is thought to act upon these receptors, by influencing the body to produce its own cannabinoids in order to rebalance itself.
REM Behavior Disorder: REM behavior disorder (RBD) is a parasomnia disorder characterized by shouting, becoming physically agitated, or otherwise acting out during sleep. For many, RBD is a symptom of a larger, more serious condition or disorder, such as Alzheimer’s disease or PTSD. CBD oil minimizes the symptoms of RBD, and also alleviates the anxiety and painful symptoms that often accompany disorders that lead to RBD.
To make matters more confusing, nine states (including California, Washington, and Colorado) let residents buy cannabis-based products with or without THC. Nearly two dozen other “medical marijuana states” allow the sale of cannabis, including capsules, tinctures, and other items containing CBD or THC, at licensed dispensaries to people whose doctors have certified that they have an approved condition (the list varies by state but includes chronic pain, PTSD, cancer, autism, Crohn’s disease, and multiple sclerosis). Sixteen more states legalized CBD for certain diseases.
A group of 15 patients who received CBD over a period ranging from one month to one year were surveyed to gather various data. The researchers sought information about the patient and the caregiver, changes observed in the seizures, neuropsychological effects, side effects and the family’s overall perception following the use of cannabidiol. This simple observational study identified some very encouraging findings:
CBD may offer an option for treating different types of chronic pain. A study from the European Journal of Pain showed, using an animal model, CBD applied on the skin could help lower pain and inflammation due to arthritis. Another study demonstrated the mechanism by which CBD inhibits inflammatory and neuropathic pain, two of the most difficult types of chronic pain to treat. More study in humans is needed in this area to substantiate the claims of CBD proponents about pain control.
CBD is extracted from marijuana plants as either an oil or powder. These can be mixed into creams or gels. They can be put into capsules and taken orally, or rubbed on your skin. The multiple sclerosis drug nabiximols is sprayed as a liquid into your mouth. How CBD should be used depends largely on what it’s being used for. Talk to your doctor before using CBD oil. It hasn’t been approved by the U.S. Food and Drug Administration (FDA) for any medical uses, and it can have side effects.
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Thank you for your questions. Marijuana and hemp are two extremely different strains of the same cannabis sativa plant that have been bred over thousands of years to have entirely different purposes. (Hemp is not the male version of the marijuana plant.) They both contain CBD. Hemp only contains CBD whereas marijuana contains CBD and perhaps a hundred or so other chemicals with a variety of functions, such as THC, the molecule that makes people “high”. Any medicine can have different effects on different people. For example, Benadryl makes some people sleepy yet can make others wide-awake. So, it is not inconsistent for a particular medicine to cause a symptom in one person and to help alleviate it in another. So while many people experience relaxation with CBD, so people do experience the “paradoxical” effect of irritability.

CBD can be applied to the skin both as a cream and as a concentrate or tincture. When you apply CBD Concentrate to the skin, you do not need to apply as much as the cream because of the higher concentration of CBD. Due to its gluey texture, it will adhere very well to the skin and if the CBD oil has a dark color, it will give a stain. Just leave it on as long as possible. If necessary, you can easily remove the remaining concentrate with edible oil from the skin.

Featuring the same benefits as our pure RSHO™ hemp oil in a reduced potency, another of our midrange products, RSHO™ liquid, contains 31 mg of CBD per serving. Available in Green, Blue, and Gold Label oils, RSHO™ liquid combines our flagship RSHO™ with medium chain triglyceride (MCT) oil derived from wholesome coconut oil and sustainably sourced palm oil. Unlike RSHO™ pure hemp oils, RSHO™ liquid doesn’t need to be refrigerated, making it convenient to store wherever you need it most.


CBD may be best known for its relaxing, calming effects. CBD reduces autonomic arousal, having the inverse effect of THC on the body. CBD’s anti-anxiety effect is why many in the cannabis community talk about how CBD relieves paranoia, although that is not scientifically proven yet. CBD is also known for its anti-nausea and pain relieving effects. It really depends on why your body’s specific needs and the quantity in which you take CBD.

More human studies are needed to fully understand the range of risks and side effects that CBD oil may cause. Studies of CBD oil aren’t common. This is partially because Schedule 1 substances like cannabis are highly regulated, causing some obstacles for researchers. With the legalization of marijuana products, more research is possible, and more answers will come.

Vaporizers – Many state-licensed cannabis dispensaries offer high CBD strains of cannabis flower. This allows for reduced risk of paranoia while allowing for a high medicinal dose of CBD. Vaporizers are used to heat up the flower and remove the properties or compounds of the plant that you are looking for without combustion or smoking. Vaporizers use convection much like a convection oven.


Transparency: cbdMD seems to be going through a transition with their third-party testing practices. Until recently, they only released a lab report for the CBD concentrate they use for all their products, but would not show potency testing for individual products. That seems to be changing. Currently, the only lab report on the website is for their concentrate (and it’s over a year old). But if you contact customer service, they’ll send you a lab report for any product. 

There is a strong sedative quality to CBD hemp oil, making it a popular remedy for people with insomnia, sleeplessness, interrupted sleep, post-traumatic stress disorder, restless leg disorder, and other night-time issues. Dr. Scott Shannon, Assistant Clinical Professor of Psychiatry at the University of Colorado School of Medicine, USA, published a report in the Permanete Journal, in which he recommended either inhaling a small amount of CBD oil, applying it to one’s chest, or even putting a few drops on one’s pillow to help get a good night’s sleep.
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